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Very poor/Substantial Metabolizers, CYP2D6 The formation on the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About seven% from the population has minimized action of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These folks are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic ant